IUBMB Enzyme Nomenclature

EC 4.4.1.8

Accepted name: cystathionine β-lyase

Reaction: L-cystathionine + H2O = L-homocysteine + pyruvate + NH3 (overall reaction)
(1a) L-cystathionine = L-homocysteine + 2-aminoprop-2-enoate
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)

For diagram of reaction click here.

Other name(s): β-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionine L-homocysteine-lyase (deaminating); CBL

Systematic name: L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)

Comments: A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing L-homocysteine and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds. Possibly identical, in yeast, with EC 4.4.1.6 S-alkylcysteine lyase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-05-4

References:

1. Anderson, N.W. and Thompson, J.F. Cystine lyase: β-cystathionase from turnip roots. Phytochemistry 18 (1979) 1953-1958.

2. Flavin, M. and Slaughter, C. Cystathionine cleavage enzymes of Neurospora. J. Biol. Chem. 239 (1964) 2212-2219. [PMID: 14209950]

[EC 4.4.1.8 created 1972]


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