IUBMB Enzyme Nomenclature

EC 4.4.1.8

Accepted name: cystathionine β-lyase

Reaction: L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate

Other name(s): β-cystathionase; cystine lyase; cystathionine L-homocysteine-lyase (deaminating); L-cystathionine L-homocysteine-lyase (deaminating)

Systematic name: L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)

Comments: A pyridoxal-phosphate protein. The enzyme from some sources also acts on L-cystine, forming pyruvate, ammonia and cysteine persulfide, and a number of related compounds. Possibly identical, in yeast, with EC 4.4.1.6 S-alkylcysteine lyase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9055-05-4

References:

1. Anderson, N.W. and Thompson, J.F. Cystine lyase: β-cystathionase from turnip roots. Phytochemistry 18 (1979) 1953-1958.

2. Flavin, M. and Slaughter, C. Cystathionine cleavage enzymes of Neurospora. J. Biol. Chem. 239 (1964) 2212-2219. [PMID: 14209950]

[EC 4.4.1.8 created 1972]


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