IUBMB Enzyme Nomenclature


Accepted name: guanylate cyclase

Reaction: GTP = 3',5'-cyclic GMP + diphosphate

For diagram of reaction click here

Other name(s): guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing)

Systematic name: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)

Comments: Also acts on ITP and dGTP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9054-75-5


1. Garbers, D.L., Suddath, J.L. and Hardman, J.G. Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity. Biochim. Biophys. Acta 377 (1975) 174-185. [PMID: 235291]

2. Hardman, J.G. and Sutherland, E.W. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine triphosphate. J. Biol. Chem. 244 (1969) 6363-6370. [PMID: 4982201]

[EC created 1972]

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