Reaction: GTP = 3',5'-cyclic GMP + diphosphate
For diagram of reaction click here
Other name(s): guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing)
Systematic name: GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Comments: Also acts on ITP and dGTP.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9054-75-5
1. Garbers, D.L., Suddath, J.L. and Hardman, J.G. Enzymatic formation of inosine 3',5'-monophosphate and of 2'-deoxyguanosine 3',5'-monophosphate. Inosinate and deoxyguanylate cyclase activity. Biochim. Biophys. Acta 377 (1975) 174-185. [PMID: 235291]
2. Hardman, J.G. and Sutherland, E.W. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3',5'-monophosphate from guanosine triphosphate. J. Biol. Chem. 244 (1969) 6363-6370. [PMID: 4982201]