IUBMB Enzyme Nomenclature


Accepted name: ferrochelatase

Reaction: protoheme + 2 H+ = protoporphyrin + Fe2+

For diagram of reaction click here.

Other name(s): ferro-protoporphyrin chelatase; iron chelatase; heme synthetase; heme synthase; protoheme ferro-lyase

Systematic name: protoheme ferro-lyase (protoporphyrin-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9012-93-5


1. Bloomer, J.R., Hill, H.D., Morton, K.O., Anderson-Burnham, L.A. and Straka, J.G. The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase. J.Biol. Chem. 262 (1987) 667-671. [PMID: 3805002]

2. Porra, R.J. and Jones, O.T.G. Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract. Biochem. J. 87 (1963) 181-185.[PMID: 13972328]

3. Porra, R.J. and Jones, O.T.G. Studies on ferrochelatase. 2. An investigation of the role of ferrochelatase in the biosynthesis of various haem prosthetic groups. Biochem. J. 87 (1963) 186-192.[PMID: 13972329]

[EC created 1965]

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