Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature. Recommendations

Contents EC 4.1.1.1 - EC 4.99.1.6

EC 4 Lyases

EC 4.1 Carbon-Carbon Lyases

EC 4.1.1 Carboxy-Lyases

EC 4.1.1.1 pyruvate decarboxylase
EC 4.1.1.2 oxalate decarboxylase
EC 4.1.1.3 oxaloacetate decarboxylase
EC 4.1.1.4 acetoacetate decarboxylase
EC 4.1.1.5 acetolactate decarboxylase
EC 4.1.1.6 aconitate decarboxylase
EC 4.1.1.7 benzoylformate decarboxylase
EC 4.1.1.8 oxalyl-CoA decarboxylase
EC 4.1.1.9 malonyl-CoA decarboxylase
EC 4.1.1.10 deleted, included in EC 4.1.1.12
EC 4.1.1.11 aspartate 1-decarboxylase
EC 4.1.1.12 aspartate 4-decarboxylase
EC 4.1.1.13 deleted
EC 4.1.1.14 valine decarboxylase
EC 4.1.1.15 glutamate decarboxylase
EC 4.1.1.16 hydroxyglutamate decarboxylase
EC 4.1.1.17 ornithine decarboxylase
EC 4.1.1.18 lysine decarboxylase
EC 4.1.1.19 arginine decarboxylase
EC 4.1.1.20 diaminopimelate decarboxylase
EC 4.1.1.21 phosphoribosylaminoimidazole carboxylase
EC 4.1.1.22 histidine decarboxylase
EC 4.1.1.23 orotidine-5'-phosphate decarboxylase
EC 4.1.1.24 aminobenzoate decarboxylase
EC 4.1.1.25 tyrosine decarboxylase
EC 4.1.1.26 deleted, included in EC 4.1.1.28
EC 4.1.1.27 deleted, included in EC 4.1.1.28
EC 4.1.1.28 aromatic-L-amino-acid decarboxylase
EC 4.1.1.29 sulfoalanine decarboxylase
EC 4.1.1.30 pantothenoylcysteine decarboxylase
EC 4.1.1.31 phosphoenolpyruvate carboxylase
EC 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
EC 4.1.1.33 diphosphomevalonate decarboxylase
EC 4.1.1.34 dehydro-L-gulonate decarboxylase
EC 4.1.1.35 UDP-glucuronate decarboxylase
EC 4.1.1.36 phosphopantothenoylcysteine decarboxylase
EC 4.1.1.37 uroporphyrinogen decarboxylase
EC 4.1.1.38 phosphoenolpyruvate carboxykinase (diphosphate)
EC 4.1.1.39 ribulose-bisphosphate carboxylase
EC 4.1.1.40 hydroxypyruvate decarboxylase
EC 4.1.1.41 methylmalonyl-CoA decarboxylase
EC 4.1.1.42 carnitine decarboxylase
EC 4.1.1.43 phenylpyruvate decarboxylase
EC 4.1.1.44 4-carboxymuconolactone decarboxylase
EC 4.1.1.45 aminocarboxymuconate-semialdehyde decarboxylase
EC 4.1.1.46 o-pyrocatechuate decarboxylase
EC 4.1.1.47 tartronate-semialdehyde synthase
EC 4.1.1.48 indole-3-glycerol-phosphate synthase
EC 4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)
EC 4.1.1.50 adenosylmethionine decarboxylase
EC 4.1.1.51 3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase
EC 4.1.1.52 6-methylsalicylate decarboxylase
EC 4.1.1.53 phenylalanine decarboxylase
EC 4.1.1.54 dihydroxyfumarate decarboxylase
EC 4.1.1.55 4,5-dihydroxyphthalate decarboxylase
EC 4.1.1.56 3-oxolaurate decarboxylase
EC 4.1.1.57 methionine decarboxylase
EC 4.1.1.58 orsellinate decarboxylase
EC 4.1.1.59 gallate decarboxylase
EC 4.1.1.60 stipitatonate decarboxylase
EC 4.1.1.61 4-hydroxybenzoate decarboxylase
EC 4.1.1.62 gentisate decarboxylase
EC 4.1.1.63 protocatechuate decarboxylase
EC 4.1.1.64 2,2-dialkylglycine decarboxylase (pyruvate)
EC 4.1.1.65 phosphatidylserine decarboxylase
EC 4.1.1.66 uracil-5-carboxylate decarboxylase
EC 4.1.1.67 UDP-galacturonate decarboxylase
EC 4.1.1.68 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase
EC 4.1.1.69 3,4-dihydroxyphthalate decarboxylase
EC 4.1.1.70 glutaconyl-CoA decarboxylase
EC 4.1.1.71 2-oxoglutarate decarboxylase
EC 4.1.1.72 branched-chain-2-oxoacid decarboxylase
EC 4.1.1.73 tartrate decarboxylase
EC 4.1.1.74 indolepyruvate decarboxylase
EC 4.1.1.75 5-guanidino-2-oxopentanoate decarboxylase
EC 4.1.1.76 arylmalonate decarboxylase
EC 4.1.1.77 2-oxo-3-hexenedioate decarboxylase
EC 4.1.1.78 acetylenedicarboxylate decarboxylase
EC 4.1.1.79 sulfopyruvate decarboxylase
EC 4.1.1.80 4-hydroxyphenylpyruvate decarboxylase
EC 4.1.1.81 threonine-phosphate decarboxylase
EC 4.1.1.82 phosphonopyruvate decarboxylase
EC 4.1.1.83 4-hydroxyphenylacetate decarboxylase
EC 4.1.1.84 D-dopachrome decarboxylase
EC 4.1.1.85 3-dehydro-L-gulonate-6-phosphate decarboxylase
EC 4.1.1.86 diaminobutyrate decarboxylase
EC 4.1.1.87 malonyl-S-ACP decarboxylase
EC 4.1.1.88 biotin-independent malonate decarboxylase
EC 4.1.1.89 biotin-dependent malonate decarboxylase
EC 4.1.1.90 peptidyl-glutamate 4-carboxylase
EC 4.1.1.91 salicylate decarboxylase
EC 4.1.1.92 indole-3-carboxylate decarboxylase
EC 4.1.1.93 pyrrole-2-carboxylate decarboxylase
EC 4.1.1.94 ethylmalonyl-CoA decarboxylase
EC 4.1.1.95 L-glutamyl-[BtrI acyl-carrier protein] decarboxylase
EC 4.1.1.96 carboxynorspermidine decarboxylase
EC 4.1.1.97 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
EC 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase
EC 4.1.1.99 phosphomevalonate decarboxylase
EC 4.1.1.100 prephenate decarboxylase
EC 4.1.1.101 malolactic enzyme
EC 4.1.1.102 phenacrylate decarboxylase
EC 4.1.1.103 γ-resorcylate decarboxylase

EC 4.1.2 Aldehyde-Lyases

EC 4.1.2.1 deleted, included in EC 4.1.3.16
EC 4.1.2.2 ketotetrose-phosphate aldolase
EC 4.1.2.3 deleted
EC 4.1.2.4 deoxyribose-phosphate aldolase
EC 4.1.2.5 L-threonine aldolase
EC 4.1.2.6 deleted
EC 4.1.2.7 deleted, included in EC 4.1.2.13
EC 4.1.2.8 indole-3-glycerol-phosphate lyase
EC 4.1.2.9 phosphoketolase
EC 4.1.2.10 mandelonitrile lyase
EC 4.1.2.11 hydroxymandelonitrile lyase
EC 4.1.2.12 ketopantoaldolase
EC 4.1.2.13 fructose-bisphosphate aldolase
EC 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
EC 4.1.2.15 now EC 2.5.1.54
EC 4.1.2.16 now EC 2.5.1.55
EC 4.1.2.17 L-fuculose-phosphate aldolase
EC 4.1.2.18 2-dehydro-3-deoxy-L-pentonate aldolase
EC 4.1.2.19 rhamnulose-1-phosphate aldolase
EC 4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
EC 4.1.2.21 2-dehydro-3-deoxy-6-phosphogalactonate aldolase
EC 4.1.2.22 fructose-6-phosphate phosphoketolase
EC 4.1.2.23 3-deoxy-D-manno-octulosonate aldolase
EC 4.1.2.24 dimethylaniline-N-oxide aldolase
EC 4.1.2.25 dihydroneopterin aldolase
EC 4.1.2.26 phenylserine aldolase
EC 4.1.2.27 sphinganine-1-phosphate aldolase
EC 4.1.2.28 2-dehydro-3-deoxy-D-pentonate aldolase
EC 4.1.2.29 5-dehydro-2-deoxyphosphogluconate aldolase
EC 4.1.2.30 transferred now EC 1.14.14.32
EC 4.1.2.31 deleted, included in EC 4.1.3.16
EC 4.1.2.32 trimethylamine-oxide aldolase
EC 4.1.2.33 fucosterol-epoxide lyase
EC 4.1.2.34 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
EC 4.1.2.35 propioin synthase
EC 4.1.2.36 lactate aldolase
EC 4.1.2.37 hydroxynitrilase
EC 4.1.2.37 deleted now covered by EC 4.1.2.46 and EC 4.1.2.47
EC 4.1.2.38 benzoin aldolase
EC 4.1.2.39 deleted, same as EC 4.1.2.37
EC 4.1.2.40 tagatose-bisphosphate aldolase
EC 4.1.2.41 vanillin synthase
EC 4.1.2.42 D-threonine aldolase
EC 4.1.2.43 3-hexulose-6-phosphate synthase
EC 4.1.2.44 2,3-epoxybenzoyl-CoA dihydrolase
EC 4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase
EC 4.1.2.46 aliphatic (R)-hydroxynitrile lyase
EC 4.1.2.47 (S)-hydroxynitrile lyase
EC 4.1.2.48 low-specificity L-threonine aldolase
EC 4.1.2.49 L-allo-threonine aldolase
EC 4.1.2.50 6-carboxytetrahydropterin synthase
EC 4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
EC 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
EC 4.1.2.53 2-keto-3-deoxy-L-rhamnonate aldolase
EC 4.1.2.54 L-threo-3-deoxy-hexylosonate aldolase
EC 4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase
EC 4.1.2.56 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase
EC 4.1.2.57 sulfofructosephosphate aldolase
EC 4.1.2.58 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase

EC 4.1.3 Oxo-Acid-Lyases

EC 4.1.3.1 isocitrate lyase
EC 4.1.3.2 now EC 2.3.3.9
EC 4.1.3.3 N-acetylneuraminate lyase
EC 4.1.3.4 hydroxymethylglutaryl-CoA lyase
EC 4.1.3.5 now EC 2.3.3.10
EC 4.1.3.6 citrate (pro-3S)-lyase
EC 4.1.3.7 now EC 2.3.3.1
EC 4.1.3.8 now EC 2.3.3.8
EC 4.1.3.9 now EC 2.3.3.11
EC 4.1.3.10 now EC 2.3.3.7
EC 4.1.3.11 now EC 2.3.3.12
EC 4.1.3.12 now EC 2.3.3.13
EC 4.1.3.13 oxalomalate lyase
EC 4.1.3.14 L-erythro-3-hydroxyaspartate aldolase
EC 4.1.3.15 now EC 2.2.1.5
EC 4.1.3.16 4-hydroxy-2-oxoglutarate aldolase
EC 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
EC 4.1.3.18 now EC 2.2.1.6
EC 4.1.3.19 now EC 2.5.1.56
EC 4.1.3.20 now EC 2.5.1.57
EC 4.1.3.21 now EC 2.3.3.14
EC 4.1.3.22 citramalate lyase
EC 4.1.3.23 now EC 2.3.3.2
EC 4.1.3.24 malyl-CoA lyase
EC 4.1.3.25 (S)-citramalyl-CoA lyase
EC 4.1.3.26 3-hydroxy-3-isohexenylglutaryl-CoA lyase
EC 4.1.3.27 anthranilate synthase
EC 4.1.3.28 now EC 2.3.3.3
EC 4.1.3.29 now EC 2.3.3.4
EC 4.1.3.30 methylisocitrate lyase
EC 4.1.3.31 now EC 2.3.3.5
EC 4.1.3.32 2,3-dimethylmalate lyase
EC 4.1.3.33 now EC 2.3.3.6
EC 4.1.3.34 citryl-CoA lyase
EC 4.1.3.35 (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase
EC 4.1.3.36 1,4-dihydroxy-2-naphthoyl-CoA synthase
EC 4.1.3.37 now EC 2.2.1.7
EC 4.1.3.38 aminodeoxychorismate lyase
EC 4.1.3.39 4-hydroxy-2-oxovalerate aldolase
EC 4.1.3.40 chorismate lyase
EC 4.1.3.41 3-hydroxy-D-aspartate aldolase
EC 4.1.3.42 (4S)-4-hydroxy-2-oxoglutarate aldolase
EC 4.1.3.43 4-hydroxy-2-oxohexanoate aldolase
EC 4.1.3.44 tRNA 4-demethylwyosine synthase (AdoMet-dependent)
EC 4.1.3.45 3-hydroxybenzoate synthase
EC 4.1.3.46 (R)-citramalyl-CoA lyase

EC 4.1.99 Other Carbon-Carbon Lyases

EC 4.1.99.1 tryptophanase
EC 4.1.99.2 tyrosine phenol-lyase
EC 4.1.99.3 deoxyribodipyrimidine photo-lyase
EC 4.1.99.4 now EC 3.5.99.7
EC 4.1.99.5 aldehyde oxygenase (deformylating)
EC 4.1.99.6 now EC 4.2.3.6
EC 4.1.99.7 now EC 4.2.3.9
EC 4.1.99.8 now EC 4.2.3.14
EC 4.1.99.9 now EC 4.2.3.15
EC 4.1.99.10 now EC 4.2.3.16
EC 4.1.99.11 benzylsuccinate synthase
EC 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
EC 4.1.99.13 (6-4)DNA photolyase
EC 4.1.99.14 spore photoproduct lyase
EC 4.1.99.15 deleted covered by EC 4.1.99.14
EC 4.1.99.16 geosmin synthase
EC 4.1.99.17 phosphomethylpyrimidine synthase
EC 4.1.99.18 transferred now EC 4.1.99.22 and EC 4.6.1.17
EC 4.1.99.19 2-iminoacetate synthase
EC 4.1.99.20 3-amino-4-hydroxybenzoate synthase
EC 4.1.99.21 transferred now EC 4.2.3.154
EC 4.1.99.22 GTP 3',8-cyclase

EC 4.2 Carbon-Oxygen Lyases

EC 4.2.1 Hydro-Lyases

EC 4.2.1.1 carbonic anhydrase
EC 4.2.1.2 fumarate hydratase
EC 4.2.1.3 aconitate hydratase
EC 4.2.1.4 deleted now known to be a partial reaction catalysed by EC 4.2.1.3
EC 4.2.1.5 arabinonate dehydratase
EC 4.2.1.6 galactonate dehydratase
EC 4.2.1.7 altronate dehydratase
EC 4.2.1.8 mannonate dehydratase
EC 4.2.1.9 dihydroxy-acid dehydratase
EC 4.2.1.10 3-dehydroquinate dehydratase
EC 4.2.1.11 phosphopyruvate hydratase
EC 4.2.1.12 phosphogluconate dehydratase
EC 4.2.1.13 now EC 4.3.1.17
EC 4.2.1.14 now EC 4.3.1.18
EC 4.2.1.15 now EC 4.4.1.1
EC 4.2.1.16 now EC 4.3.1.19
EC 4.2.1.17 enoyl-CoA hydratase
EC 4.2.1.18 methylglutaconyl-CoA hydratase
EC 4.2.1.19 imidazoleglycerol-phosphate dehydratase
EC 4.2.1.20 tryptophan synthase
EC 4.2.1.21 now EC 4.2.1.22
EC 4.2.1.22 cystathionine β-synthase
EC 4.2.1.23 deleted
EC 4.2.1.24 porphobilinogen synthase
EC 4.2.1.25 L-arabinonate dehydratase
EC 4.2.1.26 now EC 4.3.1.21
EC 4.2.1.27 acetylenecarboxylate hydratase
EC 4.2.1.28 propanediol dehydratase
EC 4.2.1.29 now EC 4.99.1.6
EC 4.2.1.30 glycerol dehydratase
EC 4.2.1.31 maleate hydratase
EC 4.2.1.32 L(+)-tartrate dehydratase
EC 4.2.1.33 3-isopropylmalate dehydratase
EC 4.2.1.34 (S)-2-methylmalate dehydratase
EC 4.2.1.35 (R)-2-methylmalate dehydratase
EC 4.2.1.36 homoaconitate hydratase
EC 4.2.1.37 now EC 3.3.2.4
EC 4.2.1.38 now EC 4.3.1.20
EC 4.2.1.39 gluconate dehydratase
EC 4.2.1.40 glucarate dehydratase
EC 4.2.1.41 5-dehydro-4-deoxyglucarate dehydratase
EC 4.2.1.42 galactarate dehydratase
EC 4.2.1.43 2-dehydro-3-deoxy-L-arabinonate dehydratase
EC 4.2.1.44 myo-inosose-2 dehydratase
EC 4.2.1.45 CDP-glucose 4,6-dehydratase
EC 4.2.1.46 dTDP-glucose 4,6-dehydratase
EC 4.2.1.47 GDP-mannose 4,6-dehydratase
EC 4.2.1.48 D-glutamate cyclase
EC 4.2.1.49 urocanate hydratase
EC 4.2.1.50 pyrazolylalanine synthase
EC 4.2.1.51 prephenate dehydratase
EC 4.2.1.52 transferred, now EC 4.3.3.7
EC 4.2.1.53 oleate hydratase
EC 4.2.1.54 lactoyl-CoA dehydratase
EC 4.2.1.55 3-hydroxybutyryl-CoA dehydratase
EC 4.2.1.56 itaconyl-CoA hydratase
EC 4.2.1.57 isohexenylglutaconyl-CoA hydratase
EC 4.2.1.58 deleted now covered by EC 4.2.1.59
EC 4.2.1.59 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
EC 4.2.1.60 deleted now covered by EC 4.2.1.59
EC 4.2.1.61 deleted now covered by EC 4.2.1.59
EC 4.2.1.62 5α-hydroxysteroid dehydratase
EC 4.2.1.63 now EC 3.3.2.3
EC 4.2.1.64 now EC 3.3.2.3
EC 4.2.1.65 3-cyanoalanine hydratase
EC 4.2.1.66 cyanide hydratase
EC 4.2.1.67 D-fuconate dehydratase
EC 4.2.1.68 L-fuconate dehydratase
EC 4.2.1.69 cyanamide hydratase
EC 4.2.1.70 pseudouridylate synthase
EC 4.2.1.71 identical to EC 4.2.1.27
EC 4.2.1.72 now EC 4.1.1.78
EC 4.2.1.73 protoaphin-aglucone dehydratase (cyclizing)
EC 4.2.1.74 long-chain-enoyl-CoA hydratase
EC 4.2.1.75 uroporphyrinogen-III synthase
EC 4.2.1.76 UDP-glucose 4,6-dehydratase
EC 4.2.1.77 trans-L-3-hydroxyproline dehydratase
EC 4.2.1.78 (S)-norcoclaurine synthase
EC 4.2.1.79 2-methylcitrate dehydratase
EC 4.2.1.80 2-oxopent-4-enoate hydratase
EC 4.2.1.81 D(–)-tartrate dehydratase
EC 4.2.1.82 xylonate dehydratase
EC 4.2.1.83 4-oxalmesaconate hydratase
EC 4.2.1.84 nitrile hydratase
EC 4.2.1.85 dimethylmaleate hydratase
EC 4.2.1.86 16-dehydroprogesterone hydratase
EC 4.2.1.86 deleted identical to EC 4.2.1.98
EC 4.2.1.87 octopamine dehydratase
EC 4.2.1.88 synephrine dehydratase
EC 4.2.1.89 deleted, due to EC 2.8.3.21 and EC 4.2.1.149
EC 4.2.1.90 L-rhamnonate dehydratase
EC 4.2.1.91 arogenate dehydratase
EC 4.2.1.92 hydroperoxide dehydratase
EC 4.2.1.93 ATP-dependent NAD(P)H-hydrate dehydratase
EC 4.2.1.94 scytalone dehydratase
EC 4.2.1.95 kievitone hydratase
EC 4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase
EC 4.2.1.97 phaseollidin hydratase
EC 4.2.1.98 16α-hydroxyprogesterone dehydratase
EC 4.2.1.99 2-methylisocitrate dehydratase
EC 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase
EC 4.2.1.101 trans-feruloyl-CoA hydratase
EC 4.2.1.102 now EC 4.2.1.100
EC 4.2.1.103 cyclohexyl-isocyanide hydratase
EC 4.2.1.104 cyanase
EC 4.2.1.105 2-hydroxyisoflavanone dehydratase
EC 4.2.1.106 bile-acid 7α-dehydratase
EC 4.2.1.107 3α,7α,12αtrihydroxy-5β-cholest-24-enoyl-CoA dehydratase
EC 4.2.1.108 ectoine synthase
EC 4.2.1.109 methylthioribulose 1-phosphate dehydratase
EC 4.2.1.110 aldos-2-ulose dehydratase
EC 4.2.1.111 1,5-anhydro-D-fructose dehydratase
EC 4.2.1.112 acetylene hydratase
EC 4.2.1.113 o-succinylbenzoate synthase
EC 4.2.1.114 methanogen homoaconitase
EC 4.2.1.115 UDP-N-acetylglucosamine 4,6-dehydratase (inverting)
EC 4.2.1.116 3-hydroxypropionyl-CoA dehydratase
EC 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
EC 4.2.1.118 3-dehydroshikimate dehydratase
EC 4.2.1.119 enoyl-CoA hydratase 2
EC 4.2.1.120 4-hydroxybutanoyl-CoA dehydratase
EC 4.2.1.121 colneleate synthase
EC 4.2.1.122 tryptophan synthase (indole-salvaging)
EC 4.2.1.123 tetrahymanol synthase
EC 4.2.1.124 arabidiol synthase
EC 4.2.1.125 dammarenediol II synthase
EC 4.2.1.126 N-acetylmuramic acid 6-phosphate etherase
EC 4.2.1.127 linalool dehydratase
EC 4.2.1.128 lupan-3β,20-diol synthase
EC 4.2.1.129 squalene—hopanol cyclase
EC 4.2.1.130 D-lactate dehydratase
EC 4.2.1.131 carotenoid 1,2-hydratase
EC 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase
EC 4.2.1.133 copal-8-ol diphosphate hydratase
EC 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
EC 4.2.1.135 UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)
EC 4.2.1.136 ADP-dependent NAD(P)H-hydrate dehydratase
EC 4.2.1.137 sporulenol synthase
EC 4.2.1.138 (+)-caryolan-1-ol synthase
EC 4.2.1.139 medicarpin synthase
EC 4.2.1.140 gluconate/galactonate dehydratase
EC 4.2.1.141 2-dehydro-3-deoxy-D-arabinonate dehydratase
EC 4.2.1.142 5'-oxoaverantin cyclase
EC 4.2.1.143 versicolorin B synthase
EC 4.2.1.144 3-amino-5-hydroxybenzoate synthase
EC 4.2.1.145 capreomycidine synthase
EC 4.2.1.146 L-galactonate dehydratase
EC 4.2.1.147 5,6,7,8-tetrahydromethanopterin hydro-lyase
EC 4.2.1.148 2-methylfumaryl-CoA hydratase
EC 4.2.1.149 crotonobetainyl-CoA hydratase
EC 4.2.1.150 short-chain-enoyl-CoA hydratase
EC 4.2.1.151 chorismate dehydratase
EC 4.2.1.152 hydroperoxy icosatetraenoate dehydratase
EC 4.2.1.153 3-methylfumaryl-CoA hydratase
EC 4.2.1.154 tetracenomycin F2 cyclase
EC 4.2.1.155 methylthioacryloyl-CoA hydratase
EC 4.2.1.156 L-talarate dehydratase
EC 4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase
EC 4.2.1.158 galactarate dehydratase (D-threo-forming)
EC 4.2.1.159 dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase
EC 4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
EC 4.2.1.161 bisanhydrobacterioruberin hydratase
EC 4.2.1.162 6-deoxy-6-sulfo-D-gluconate dehydratase
EC 4.2.1.163 2-oxo-hept-4-ene-1,7-dioate hydratase
EC 4.2.1.164 dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase
EC 4.2.1.165 chlorophyllide a 31-hydratase
EC 4.2.1.166 phosphinomethylmalate isomerase
EC 4.2.1.167 (R)-2-hydroxyglutaryl-CoA dehydratase
EC 4.2.1.168 GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase
EC 4.2.1.169 3-vinyl bacteriochlorophyllide d 31-hydratase
EC 4.2.1.170 2-(ω-methylthio)alkylmalate dehydratase

EC 4.2.2 Acting on Polysaccharides

EC 4.2.2.1 hyaluronate lyase
EC 4.2.2.2 pectate lyase
EC 4.2.2.3 mannuronate-specific alginate lyase
EC 4.2.2.4 now EC 4.2.2.20 and EC 4.2.2.21
EC 4.2.2.5 chondroitin AC lyase
EC 4.2.2.6 oligogalacturonide lyase
EC 4.2.2.7 heparin lyase
EC 4.2.2.8 heparin-sulfate lyase
EC 4.2.2.9 pectate disaccharide-lyase
EC 4.2.2.10 pectin lyase
EC 4.2.2.11 guluronate-specific alginate lyase
EC 4.2.2.12 xanthan lyase
EC 4.2.2.13 exo-(1→4)-α-D-glucan lyase
EC 4.2.2.14 glucuronan lyase
EC 4.2.2.15 anhydrosialidase
EC 4.2.2.16 levan fructotransferase (DFA-IV-forming)
EC 4.2.2.17 inulin fructotransferase (DFA-I-forming)
EC 4.2.2.18 inulin fructotransferase (DFA-III-forming)
EC 4.2.2.19 chondroitin B lyase
EC 4.2.2.20 chondroitin-sulfate-ABC endolyase
EC 4.2.2.21 chondroitin-sulfate-ABC exolyase
EC 4.2.2.22 pectate trisaccharide-lyase
EC 4.2.2.23 rhamnogalacturonan endolyase
EC 4.2.2.24 rhamnogalacturonan exolyase
EC 4.2.2.25 gellan lyase
EC 4.2.2.26 oligo-alginate lyase

EC 4.2.3 Acting on phosphates

EC 4.2.3.1 threonine synthase
EC 4.2.3.2 ethanolamine-phosphate phospho-lyase
EC 4.2.3.3 methylglyoxal synthase
EC 4.2.3.4 3-dehydroquinate synthase
EC 4.2.3.5 chorismate synthase
EC 4.2.3.6 trichodiene synthase
EC 4.2.3.7 pentalenene synthase
EC 4.2.3.8 casbene synthase
EC 4.2.3.9 aristolochene synthase
EC 4.2.3.10 (–)-endo-fenchol synthase
EC 4.2.3.11 sabinene-hydrate synthase
EC 4.2.3.12 6-pyruvoyltetrahydropterin synthase
EC 4.2.3.13 (+)-δ-cadinene synthase
EC 4.2.3.14 deleted now covered by EC 4.2.3.119 and EC 4.2.3.120
EC 4.2.3.15 myrcene synthase
EC 4.2.3.16 (4S)-limonene synthase
EC 4.2.3.17 taxadiene synthase
EC 4.2.3.18 abieta-7,13-diene synthase
EC 4.2.3.19 ent-kaurene synthase
EC 4.2.3.20 (R)-limonene synthase
EC 4.2.3.21 vetispiradiene synthase
EC 4.2.3.22 germacradienol synthase
EC 4.2.3.23 germacrene-A synthase
EC 4.2.3.24 amorpha-4,11-diene synthase
EC 4.2.3.25 S-linalool synthase
EC 4.2.3.26 R-linalool synthase
EC 4.2.3.27 isoprene synthase
EC 4.2.3.28 ent-cassa-12,15-diene synthase
EC 4.2.3.29 ent-sandaracopimaradiene synthase
EC 4.2.3.30 ent-pimara-8(14),15-diene synthase
EC 4.2.3.31 ent-pimara-9(11),15-diene synthase
EC 4.2.3.32 levopimaradiene synthase
EC 4.2.3.33 stemar-13-ene synthase
EC 4.2.3.34 stemod-13(17)-ene synthase
EC 4.2.3.35 syn-pimara-7,15-diene synthase
EC 4.2.3.36 terpentetriene synthase
EC 4.2.3.37 epi-isozizaene synthase
EC 4.2.3.38 α-bisabolene synthase<0203a.html#> EC 4.2.3.39 epi-cedrol synthase
EC 4.2.3.40 (Z)-γ-bisabolene synthase
EC 4.2.3.41 elisabethatriene synthase
EC 4.2.3.42 aphidicolan-16β-ol synthase
EC 4.2.3.43 fusicocca-2,10(14)-diene synthase
EC 4.2.3.44 isopimara-7,15-diene synthase
EC 4.2.3.45 phyllocladan-16α-ol synthase
EC 4.2.3.46 α-farnesene synthase
EC 4.2.3.47 β-farnesene synthase
EC 4.2.3.48 (3S,6E)-nerolidol synthase
EC 4.2.3.49 (3R,6E)-nerolidol synthase
EC 4.2.3.50 (+)-α-santalene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC 4.2.3.51 β-phellandrene synthase (neryl-diphosphate-cyclizing)
EC 4.2.3.52 (4S)-β-phellandrene synthase (geranyl-diphosphate-cyclizing)
EC 4.2.3.53 (+)-endo-β-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC 4.2.3.54 (–)-endo-α-bergamotene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC 4.2.3.55 (S)-β-bisabolene synthase
EC 4.2.3.56 γ-humulene synthase
EC 4.2.3.57 (–)-β-caryophyllene synthase
EC 4.2.3.58 longifolene synthase
EC 4.2.3.59 (E)-γ-bisabolene synthase
EC 4.2.3.60 germacrene C synthase
EC 4.2.3.61 5-epiaristolochene synthase
EC 4.2.3.62 (–)-γ-cadinene synthase [(2Z,6E)-farnesyl diphosphate cyclizing]
EC 4.2.3.63 (+)-cubenene synthase
EC 4.2.3.64 (+)-epicubenol synthase
EC 4.2.3.65 zingiberene synthase
EC 4.2.3.66 β-selinene cyclase
EC 4.2.3.67 cis-muuroladiene synthase
EC 4.2.3.68 β-eudesmol synthase
EC 4.2.3.69 (+)-α-barbatene synthase
EC 4.2.3.70 patchoulol synthase
EC 4.2.3.71 (E,E)-germacrene B synthase
EC 4.2.3.72 α-gurjunene synthase
EC 4.2.3.73 valencene synthase
EC 4.2.3.74 presilphiperfolanol synthase
EC 4.2.3.75 (–)-germacrene D synthase
EC 4.2.3.76 (+)-δ-selinene synthase
EC 4.2.3.77 (+)-germacrene D synthase
EC 4.2.3.78 β-chamigrene synthase
EC 4.2.3.79 thujopsene synthase
EC 4.2.3.80 α-longipinene synthase
EC 4.2.3.81 exo-α-bergamotene synthase
EC 4.2.3.82 α-santalene synthase
EC 4.2.3.83 β-santalene synthase
EC 4.2.3.84 10-epi-γ-eudesmol synthase
EC 4.2.3.85 α-eudesmol synthase
EC 4.2.3.86 7-epi-α-selinene synthase
EC 4.2.3.87 α-guaiene synthase
EC 4.2.3.88 viridiflorene synthase
EC 4.2.3.89 (+)-β-caryophyllene synthase
EC 4.2.3.90 5-epi-α-selinene synthase
EC 4.2.3.91 cubebol synthase
EC 4.2.3.92 (+)-γ-cadinene synthase
EC 4.2.3.93 δ-guaiene synthase
EC 4.2.3.94 γ-curcumene synthase
EC 4.2.3.95 (–)-α-cuprenene synthase
EC 4.2.3.96 avermitilol synthase
EC 4.2.3.97 (–)-δ-cadinene synthase
EC 4.2.3.98 (+)-T-muurolol synthase
EC 4.2.3.99 labdatriene synthase
EC 4.2.3.100 bicyclogermacrene synthase
EC 4.2.3.101 7-epi-sesquithujene synthase
EC 4.2.3.102 sesquithujene synthase
EC 4.2.3.103 ent-isokaurene synthase
EC 4.2.3.104 α-humulene synthase
EC 4.2.3.105 tricyclene synthase
EC 4.2.3.106 (E)-β-ocimene synthase
EC 4.2.3.107 (+)-car-3-ene synthase
EC 4.2.3.108 1,8-cineole synthase
EC 4.2.3.109 (–)-sabinene synthase
EC 4.2.3.110 (+)-sabinene synthase
EC 4.2.3.111 (–)-α-terpineol synthase
EC 4.2.3.112 (+)-α-terpineol synthase
EC 4.2.3.113 terpinolene synthase
EC 4.2.3.114 γ-terpinene synthase
EC 4.2.3.115 α-terpinene synthase
EC 4.2.3.116 (+)-camphene synthase
EC 4.2.3.117 (–)-camphene synthase
EC 4.2.3.118 2-methylisoborneol synthase
EC 4.2.3.119 (–)-α-pinene synthase
EC 4.2.3.120 (–)-β-pinene synthase
EC 4.2.3.121 (+)-α-pinene synthase
EC 4.2.3.122 (+)-β-pinene synthase
EC 4.2.3.123 β-sesquiphellandrene synthase
EC 4.2.3.124 2-deoxy-scyllo-inosose synthase
EC 4.2.3.125 α-muurolene synthase
EC 4.2.3.126 γ-muurolene synthase
EC 4.2.3.127 β-copaene synthase
EC 4.2.3.128 β-cubebene synthase
EC 4.2.3.129 (+)-sativene synthase
EC 4.2.3.130 tetraprenyl-β-curcumene synthase
EC 4.2.3.131 miltiradiene synthase
EC 4.2.3.132 neoabietadiene synthase
EC 4.2.3.133 α-copaene synthase
EC 4.2.3.134 5-phosphonooxy-L-lysine phospho-lyase
EC 4.2.3.135 Δ6-protoilludene synthase
EC 4.2.3.136 α-isocomene synthase
EC 4.2.3.137 (E)-2-epi-β-caryophyllene synthase
EC 4.2.3.138 (+)-epi-α-bisabolol synthase
EC 4.2.3.139 valerena-4,7(11)-diene synthase
EC 4.2.3.140 cis-abienol synthase
EC 4.2.3.141 sclareol synthase
EC 4.2.3.142 7-epizingiberene synthase [(2Z,6Z)-farnesyl diphosphate cyclizing]
EC 4.2.3.143 kunzeaol synthase
EC 4.2.3.144 geranyllinalool synthase
EC 4.2.3.145 ophiobolin F synthase
EC 4.2.3.146 cyclooctat-9-en-7-ol synthase
EC 4.2.3.147 pimaradiene synthase
EC 4.2.3.148 cembrene C synthase
EC 4.2.3.149 nephthenol synthase
EC 4.2.3.150 cembrene A synthase
EC 4.2.3.151 pentamethylcyclopentadecatrienol synthase
EC 4.2.3.152 2-epi-5-epi-valiolone synthase
EC 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase
EC 4.2.3.154 demethyl-4-deoxygadusol synthase
EC 4.2.3.155 2-epi-valiolone synthase
EC 4.2.3.156 hydroxysqualene synthase

EC 4.2.99 Other Carbon-Oxygen Lyases

EC 4.2.99.1 now EC 4.2.2.2
EC 4.2.99.2 now EC 4.2.3.1
EC 4.2.99.3 now EC 4.2.2.2
EC 4.2.99.4 now EC 4.2.2.3
EC 4.2.99.5 deleted
EC 4.2.99.6 deleted, included in EC 4.2.2.4 and EC 4.2.2.5
EC 4.2.99.7 now EC 4.2.3.2
EC 4.2.99.8 now EC 2.5.1.47
EC 4.2.99.9 now EC 2.5.1.48
EC 4.2.99.10 now EC 2.5.1.49
EC 4.2.99.11 now EC 4.2.3.3
EC 4.2.99.12 carboxymethyloxysuccinate lyase
EC 4.2.99.13 now EC 2.5.1.50
EC 4.2.99.14 now EC 2.5.1.51
EC 4.2.99.15 now EC 2.5.1.52
EC 4.2.99.16 now EC 2.5.1.53
EC 4.2.99.17 now EC 4.2.99.14
EC 4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase
EC 4.2.99.19 now EC 4.4.1.23
EC 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
EC 4.2.99.21 isochorismate lyase
EC 4.2.99.22 tuliposide A-converting enzyme
EC 4.2.99.23 tuliposide B-converting enzyme

EC 4.3 Carbon-Nitrogen Lyases

EC 4.3.1 Ammonia-Lyases

EC 4.3.1.1 aspartate ammonia-lyase
EC 4.3.1.2 methylaspartate ammonia-lyase
EC 4.3.1.3 histidine ammonia-lyase
EC 4.3.1.4 formiminotetrahydrofolate cyclodeaminase
EC 4.3.1.5 phenylalanine ammonia-lyase
EC 4.3.1.5 transferred, now divided into EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25
EC 4.3.1.6 β-alanyl-CoA ammonia-lyase
EC 4.3.1.7 ethanolamine ammonia-lyase
EC 4.3.1.8 now EC 2.5.1.61
EC 4.3.1.9 glucosaminate ammonia-lyase
EC 4.3.1.10 serine-sulfate ammonia-lyase
EC 4.3.1.11 deleted
EC 4.3.1.12 ornithine cyclodeaminase
EC 4.3.1.13 carbamoyl-serine ammonia-lyase
EC 4.3.1.14 3-aminobutyryl-CoA ammonia-lyase
EC 4.3.1.15 diaminopropionate ammonia-lyase
EC 4.3.1.16 threo-3-hydroxy-L-aspartate ammonia-lyase
EC 4.3.1.17 L-serine ammonia-lyase
EC 4.3.1.18 D-serine ammonia-lyase
EC 4.3.1.19 threonine ammonia-lyase
EC 4.3.1.20 erythro-3-hydroxy-L-aspartate ammonia-lyase
EC 4.3.1.21 identical to EC 4.3.1.9
EC 4.3.1.22 3,4-dihydroxyphenylalanine reductive deaminase
EC 4.3.1.23 tyrosine ammonia-lyase
EC 4.3.1.24 phenylalanine ammonia-lyase
EC 4.3.1.25 phenylalanine/tyrosine ammonia-lyase
EC 4.3.1.26 transferred now EC 1.21.3.9
EC 4.3.1.27 threo-3-hydroxy-D-aspartate ammonia-lyase
EC 4.3.1.28 L-lysine cyclodeaminase
EC 4.3.1.29 D-glucosaminate-6-phosphate ammonia lyase
EC 4.3.1.30 dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase
EC 4.3.1.31 L-tryptophan ammonia lyase

EC 4.3.2 Amidine-Lyases

EC 4.3.2.1 argininosuccinate lyase
EC 4.3.2.2 adenylosuccinate lyase
EC 4.3.2.3 ureidoglycolate lyase
EC 4.3.2.4 purine imidazole-ring cyclase
EC 4.3.2.5 peptidylamidoglycolate lyase
EC 4.3.2.6 γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase

EC 4.3.3 Amine-Lyases

EC 4.3.3.1 3-ketovalidoxylamine C-N-lyase
EC 4.3.3.2 strictosidine synthase
EC 4.3.3.3 deacetylisoipecoside synthase
EC 4.3.3.4 deacetylipecoside synthase
EC 4.3.3.5 4'-demethylrebeccamycin synthase
EC 4.3.3.6 pyridoxal 5'-phosphate synthase (glutamine hydrolysing)
EC 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99 Other Carbon-Nitrogen Lyases

EC 4.3.99.1 now EC 4.2.1.104
EC 4.3.99.2 carboxybiotin decarboxylase
EC 4.3.99.3 7-carboxy-7-deazaguanine synthase
EC 4.3.99.4 choline trimethylamine-lyase

EC 4.4 Carbon-Sulfur Lyases

EC 4.4.1.1 cystathionine γ-lyase
EC 4.4.1.2 homocysteine desulfhydrase
EC 4.4.1.3 dimethylpropiothetin dethiomethylase
EC 4.4.1.4 alliin lyase
EC 4.4.1.5 lactoylglutathione lyase
EC 4.4.1.6 S-alkylcysteine lyase
EC 4.4.1.7 deleted, included in EC 2.5.1.18
EC 4.4.1.8 cystathionine β-lyase
EC 4.4.1.9 L-3-cyanoalanine synthase
EC 4.4.1.10 cysteine lyase
EC 4.4.1.11 methionine γ-lyase
EC 4.4.1.12 deleted
EC 4.4.1.13 cysteine-S-conjugate β-lyase
EC 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase
EC 4.4.1.15 D-cysteine desulfhydrase
EC 4.4.1.16 selenocysteine lyase
EC 4.4.1.17 holocytochrome-c synthase
EC 4.4.1.18 now EC 1.8.3.5
EC 4.4.1.19 phosphosulfolactate synthase
EC 4.4.1.20 leukotriene-C4 synthase
EC 4.4.1.21 S-ribosylhomocysteine lyase
EC 4.4.1.22 S-(hydroxymethyl)glutathione synthase
EC 4.4.1.23 2-hydroxypropyl-CoM lyase
EC 4.4.1.24 (2R)-sulfolactate sulfo-lyase
EC 4.4.1.25 L-cysteate sulfo-lyase
EC 4.4.1.26 olivetolic acid cyclase
EC 4.4.1.27 carbon disulfide lyase
EC 4.4.1.28 L-cysteine desulfidase
EC 4.4.1.29 phycobiliprotein cysteine-84 phycobilin lyase
EC 4.4.1.30 phycobiliprotein β-cysteine-155 phycobilin lyase
EC 4.4.1.31 phycoerythrocyanin α-cysteine-84 phycoviolobilin lyase/isomerase
EC 4.4.1.32 C-phycocyanin α-cysteine-84 phycocyanobilin lyase
EC 4.4.1.33 R-phycocyanin α-cysteine-84 phycourobilin lyase/isomerase
EC 4.4.1.34 isoprene-epoxide—glutathione S-transferase

EC 4.5 Carbon-Halide Lyases

EC 4.5.1.1 DDT-dehydrochlorinase
EC 4.5.1.2 3-chloro-D-alanine dehydrochlorinase
EC 4.5.1.3 dichloromethane dehalogenase
EC 4.5.1.4 L-2-amino-4-chloropent-4-enoate dehydrochlorinase
EC 4.5.1.5 S-carboxymethylcysteine synthase

EC 4.6 Phosphorus-Oxygen Lyases

EC 4.6.1.1 adenylate cyclase
EC 4.6.1.2 guanylate cyclase
EC 4.6.1.3 now EC 4.2.3.4
EC 4.6.1.4 now EC 4.2.3.5
EC 4.6.1.5 now EC 4.2.3.7
EC 4.6.1.6 cytidylate cyclase
EC 4.6.1.7 now EC 4.2.3.8
EC 4.6.1.8 now EC 4.2.3.10
EC 4.6.1.9 now EC 4.2.3.11
EC 4.6.1.10 now EC 4.2.3.12
EC 4.6.1.11 now EC 4.2.3.13
EC 4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
EC 4.6.1.13 phosphatidylinositol diacylglycerol-lyase
EC 4.6.1.14 glycosylphosphatidylinositol diacylglycerol-lyase
EC 4.6.1.15 FAD-AMP lyase (cyclizing)
EC 4.6.1.16 tRNA-intron lyase
EC 4.6.1.17 cyclic pyranopterin monophosphate synthase

EC 4.7 carbon-phosphorus lyases

EC 4.7.1.1 α-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase

EC 4.99 Other Lyases

EC 4.99.1.1 protoporphyrin ferrochelatase
EC 4.99.1.2 alkylmercury lyase
EC 4.99.1.3 sirohydrochlorin cobaltochelatase
EC 4.99.1.4 sirohydrochlorin ferrochelatase

EC 4.99.1.5 aliphatic aldoxime dehydratase
EC 4.99.1.6 indoleacetaldoxime dehydratase
EC 4.99.1.7 phenylacetaldoxime dehydratase
EC 4.99.1.8 heme ligase
EC 4.99.1.9 coproporphyrin ferrochelatase


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