IUBMB Enzyme Nomenclature


Accepted name: cellobiose epimerase

Reaction: cellobiose = 4-O-β-D-glucopyranosyl-D-mannose

Glossary: cellobiose = 4-O-β-D-glucopyranosyl-D-glucose

Systematic name: cellobiose 2-epimerase

Comments: The enzyme catalyses the interconversion between D-glucose and D-mannose residues at the reducing end of β-1,4-linked disaccharides by epimerizing the hydroxyl group at the C-2 position of the glucose moiety.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37318-37-9


1. Tyler, T.R. and Leatherwood, J.M. Epimerization of disaccharides by enzyme preparations from Ruminococcus albus. Arch. Biochem. Biophys. 119 (1967) 363-367. [PMID: 6069974]

2. Ito, S., Taguchi, H., Hamada, S., Kawauchi, S., Ito, H., Senoura, T., Watanabe, J., Nishimukai, M., Ito, S. and Matsui, H. Enzymatic properties of cellobiose 2-epimerase from Ruminococcus albus and the synthesis of rare oligosaccharides by the enzyme. Appl. Microbiol. Biotechnol. 79 (2008) 433-441. [PMID: 18392616]

3. Fujiwara, T., Saburi, W., Inoue, S., Mori, H., Matsui, H., Tanaka, I. and Yao, M. Crystal structure of Ruminococcus albus cellobiose 2-epimerase: structural insights into epimerization of unmodified sugar. FEBS Lett 587 (2013) 840-846. [PMID: 23462136]

[EC created 1972]

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