Reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA
For diagram click here.
Systematic name: 2-methylacyl-CoA 2-epimerase
Comments: α-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 156681-44-6
1. Schmitz, W., Fingerhut, R., Conzelmann, E. Purification and properties of an α-methylacyl-CoA racemase from rat liver. Eur. J. Biochem. 222 (1994) 313-323. [PMID: 8020470]