IUBMB Enzyme Nomenclature


Accepted name: protein disulfide-isomerase

Reaction: Catalyses the rearrangement of -S-S- bonds in proteins

Other name(s): S-S rearrangase

Systematic name: protein disulfide-isomerase

Comments: Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37318-49-3


1. De Lorenzo, F., Goldberger, R.F., Steers, E., Givol, D. and Anfinsen, C.B. Purification and properties of an enzyme from beef liver which catalyzes sulfhydryl-disulfide interchange in proteins. J. Biol. Chem. 241 (1966) 1562-1567. [PMID: 5946614]

2. Fuchs, S., De Lorenzo, F. and Anfinsen, C.B. Studies on the mechanism of the enzymic catalysis of disulfide interchange in proteins. J. Biol. Chem. 242 (1967) 398-402. [PMID: 6022836]

[EC created 1972]

Return to EC 5.3.4 home page
Return to EC 5.3 home page
Return to EC 5 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page