IUBMB Enzyme Nomenclature

EC 5.3.99.4

Accepted name: prostaglandin-I synthase

Reaction: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9α-epoxy-11α,15-dihydroxyprosta-5,13-dienoate

Other name(s): prostacyclin synthase; prostacycline synthetase; prostagladin I2 synthetase; PGI2 synthase; PGI2 synthetase

Systematic name: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase

Comments: Converts prostaglandin H2 into prostaglandin I2 (prostacyclin). A heme-thiolate protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 65802-86-0

References:

1. DeWitt, D.L. and Smith, W.L. Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein. J. Biol. Chem. 258 (1983) 3285-3293. [PMID: 6338016]

2. Ullrich, V., Castle, L. and Weber, P. Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase. Biochem. Pharmacol. 30 (1981) 2033-2036. [PMID: 7023490]

[EC 5.3.99.4 created 1984, modified 1990]


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