IUBMB Enzyme Nomenclature

EC 5.3.99.5

Accepted name: thromboxane-A synthase

Reaction: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9α,11α-epoxy-15-hydroxythromboxa-5,13-dienoate

Other name(s): thromboxane synthase; (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase

Systematic name: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase

Comments: Converts prostaglandin H2 into thromboxane A2. A heme-thiolate protein.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 61276-89-9

References:

1. Shen, R.-F. and Tai, H.-H. Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. J. Biol. Chem. 261 (1986) 11592-11599. [PMID: 3745158]

2. Ullrich, V. and Haurand, M. Thromboxane synthase as a cytochrome P450 enzyme. Adv. Prostaglandin Thromboxane Res. 11 (1983) 105-110.

[EC 5.3.99.5 created 1984, modified 1990]


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