IUBMB Enzyme Nomenclature


Accepted name: β-phosphoglucomutase

Reaction: β-D-glucose 1-phosphate = β-D-glucose 6-phosphate

For diagram of reaction click here.

Systematic name: β-D-glucose 1,6-phosphomutase

Comments: The enzyme requires Mg2+ and phosphorylation of an aspartate residue at the active site. The enzyme is able to autophosphorylate itself with its substrate β-D-glucose 1-phosphate. Although this is a slow reaction, only a single turnover is required for activation. Once the phosphorylated enzyme is formed, it generates the reaction intermediate β-D-glucose 1,6-bisphosphate, which can be used to phosphorylate the enzyme in subsequent cycles [4]. cf. EC, phosphoglucomutase (α-D-glucose-1,6-bisphosphate-dependent).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 68651-99-0


1. Ben-Zvi, R. and Schramm, M. A phosphoglucomutase specific for β-glucose 1-phosphate. J. Biol. Chem. 236 (1961) 2186-2189.

2. Ray, W.J., Jr. and Peck, E.J., Jr. Phosphomutases, in Boyer, P.D. (Ed.), The Enzymes, 3rd edn., vol. 6, Academic Press, New York, 1972, pp. 407-477.

3. Lahiri, S.D., Zhang, G., Dunaway-Mariano, D. and Allen, K.N. The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction. Science 299 (2003) 2067-2071. [PMID: 12637673]

4. Dai, J., Wang, L., Allen, K.N., Radstrom, P. and Dunaway-Mariano, D. Conformational cycling in β-phosphoglucomutase catalysis: reorientation of the β-D-glucose 1,6-(bis)phosphate intermediate. Biochemistry 45 (2006) 7818-7824. [PMID: 16784233]

[EC created 1984]

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