IUBMB Enzyme Nomenclature

EC 5.4.99.60

Accepted name: cobalt-precorrin-8 methylmutase

Reaction: cobalt-precorrin-8 = cobyrinate

For diagram of reaction click here.

Other name(s): cbiC (gene name)

Systematic name: precorrin-8 11,12-methylmutase

Comments: The enzyme catalyses the the conversion of cobalt-precorrin-8 to cobyrinate by methyl rearrangement, a step in the anaerobic (early cobalt insertion) pathway of adenosylcobalamin biosynthesis. The equivalent enzyme in the aerobic pathway is EC 5.4.99.61, precorrin-8X methylmutase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Xue, Y., Wei, Z., Li, X. and Gong, W. The crystal structure of putative precorrin isomerase CbiC in cobalamin biosynthesis. J. Struct. Biol. 153 (2006) 307-311. [PMID: 16427313]

2. Moore, S.J., Lawrence, A.D., Biedendieck, R., Deery, E., Frank, S., Howard, M.J., Rigby, S.E. and Warren, M.J. Elucidation of the anaerobic pathway for the corrin component of cobalamin (vitamin B12). Proc. Natl. Acad. Sci. USA 110 (2013) 14906-14911. [PMID: 23922391]

[EC 5.4.99.60 created 2014]


Return to EC 5.4.99 home page
Return to EC 5.4 home page
Return to EC 5 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page