IUBMB Enzyme Nomenclature

EC 5.99.1.3

Accepted name: DNA topoisomerase (ATP-hydrolysing)

Reaction: ATP-dependent breakage, passage and rejoining of double-stranded DNA

Other name(s): type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II;

Systematic name: DNA topoisomerase (ATP-hydrolysing)

Comments: The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC 5.99.1.2 DNA topoisomerase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 142805-56-9

References:

1. Gellert, M. DNA topoisomerases. Annu. Rev. Biochem. 50 (1981) 879-910. [PMID: 6267993]

[EC 5.99.1.3 created 1984]


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