IUBMB Enzyme Nomenclature


Accepted name: acetate—CoA ligase

Reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

Other name(s): acetyl-CoA synthetase; acetyl activating enzyme; acetate thiokinase; acyl-activating enzyme; acetyl coenzyme A synthetase; acetic thiokinase; acetyl CoA ligase; acetyl CoA synthase; acetyl-coenzyme A synthase; short chain fatty acyl-CoA synthetase; short-chain acyl-coenzyme A synthetase; ACS

Systematic name: acetate:CoA ligase (AMP-forming)

Comments: Also acts on propanoate and propenoate.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9012-31-1


1. Chou, T.C. and Lipmann, F. Separation of acetyl transfer enzymes in pigeon liver extract. J. Biol. Chem. 196 (1952) 89-103.

2. Eisenberg, M.A. The acetate-activating enzyme of Rhodospirillum rubrum. Biochim. Biophys. Acta 16 (1955) 58-65.

3. Hele, P. The acetate activating enzyme of beef heart. J. Biol. Chem. 206 (1954) 671-676.

4. Millerd, A. and Bonner, J. Acetate activation and acetoacetate formation in plant systems. Arch. Biochem. Biophys. 49 (1954) 343-355.

[EC created 1961]

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