IUBMB Enzyme Nomenclature


Accepted name: acetoacetate—CoA ligase

Reaction: ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA

For diagram click here.

Other name(s): acetoacetyl-CoA synthetase

Systematic name: acetoacetate:CoA ligase (AMP-forming)

Comments: Also acts, more slowly, on L-3-hydroxybutanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 39394-62-2


1. Fukui, T., Ito, M. and Tomita, K. Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M. Eur. J. Biochem. 127 (1982) 423-428. [PMID: 7140777]

[EC created 1984]

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