IUBMB Enzyme Nomenclature


Accepted name: long-chain-fatty-acid—luciferin-component ligase

Reaction: ATP + a long-chain fatty acid + protein = AMP + diphosphate + an acyl-protein thioester

Other name(s): acyl-protein synthetase

Systematic name: long-chain-fatty-acid:protein ligase (AMP-forming)

Comments: Together with EC long-chain-fatty-acyl-CoA reductase, enzyme forms a fatty acid reductase system that produces the substrate of EC alkanal monooxygenase (FMN-linked), thus being a component of the bacterial luciferase system.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82657-98-5


1. Riendeau, D., Rodrigues, A. and Meighen, E. Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex. J. Biol. Chem. 257 (1982) 6908-6915. [PMID: 7085612]

2. Wall, L. and Meighen, E.A. Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum. Biochemistry 25 (1986) 4315-4321.

[EC created 1986, modified 2011]

[EC created 1986]

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