Reaction: ATP + a long-chain fatty acid + protein = AMP + diphosphate + an acyl-protein thioester
Other name(s): acyl-protein synthetase
Systematic name: long-chain-fatty-acid:protein ligase (AMP-forming)
Comments: Together with EC 184.108.40.206 long-chain-fatty-acyl-CoA reductase, enzyme forms a fatty acid reductase system that produces the substrate of EC 220.127.116.11 alkanal monooxygenase (FMN-linked), thus being a component of the bacterial luciferase system.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82657-98-5
1. Riendeau, D., Rodrigues, A. and Meighen, E. Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex. J. Biol. Chem. 257 (1982) 6908-6915. [PMID: 7085612]
2. Wall, L. and Meighen, E.A. Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum. Biochemistry 25 (1986) 4315-4321.