IUBMB Enzyme Nomenclature


Accepted name: trans-feruloyl-CoA synthase

Reaction: ferulic acid + CoA + ATP = feruloyl-CoA + products of ATP breakdown

For diagram of reaction click here.

ferulate: 3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate

Other name(s): trans-feruloyl-CoA synthetase; trans-ferulate:CoASH ligase (ATP-hydrolysing); ferulate:CoASH ligase (ATP-hydrolysing)

Systematic name: ferulate:CoA ligase (ATP-hydrolysing)

Comments: Requires Mg2+. It has not yet been established whether AMP + diphosphate or ADP + phosphate are formed in this reaction.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Narbad, A. and Gasson, M.J. Metabolism of ferulic acid via vanillin using a novel CoA-dependent pathway in a newly-isolated strain of Pseudomonas fluorescens. Microbiology 144 (1998) 1397-1405. [PMID: 9611814]

2. Pometto, A.L. and Crawford, D.L. Whole-cell bioconversion of vanillin to vanillic acid by Streptomyces viridosporus. Appl. Environ. Microbiol. 45 (1983) 1582-1585. [PMID: 6870241]

[EC created 2000]

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