IUBMB Enzyme Nomenclature

EC 6.2.1.4

Accepted name: succinate—CoA ligase (GDP-forming)

Reaction: GTP + succinate + CoA = GDP + phosphate + succinyl-CoA

For diagram of reaction click here.

Other name(s): succinyl-CoA synthetase (GDP-forming)

Other name(s): succinyl-CoA synthetase (GDP-forming); succinyl coenzyme A synthetase (guanosine diphosphate-forming); succinate thiokinase; succinic thiokinase; succinyl coenzyme A synthetase; succinate-phosphorylating enzyme; P-enzyme; SCS; G-STK; succinyl coenzyme A synthetase (GDP-forming); succinyl CoA synthetase; succinyl coenzyme A synthetase

Systematic name: succinate:CoA ligase (GDP-forming)

Comments: Itaconate can act instead of succinate, and ITP instead of GTP.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9014-36-2

References:

1. Hager, L.P. Succinyl CoA synthetase, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 6, Academic Press, New York, 1962, pp. 387-399.

2. Kaufman, S., Gilvarg, C., Cori, O. and Ochoa, S. Enzymatic oxidation of α-ketoglutarate and coupled phosphorylation. J. Biol. Chem. 203 (1953) 869-888.

3. Mazumder, R., Sanadi, D.R. and Rodwell, W.V. Purification and properties of hog kidney succinic thiokinase. J. Biol. Chem. 235 (1960) 2546-2550.

4. Sanadi, D.R., Gibson, D.M. and Ayengar, P. Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A. Biochim. Biophys. Acta 14 (1954) 434-436.

[EC 6.2.1.4 created 1961]


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