IUBMB Enzyme Nomenclature


Accepted name: glutamate—ammonia ligase

Reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine

Other name(s): glutamine synthetase; glutamylhydroxamic synthetase; L-glutamine synthetase

Systematic name: L-glutamate:ammonia ligase (ADP-forming)

Comments: Also acts, more slowly, on 4-methylene-L-glutamate (cf. EC 4-methyleneglutamate—ammonia ligase).

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9023-70-5


1. Elliott, W.H. Isolation of glutamine synthetase and glutamotransferase from green peas. J. Biol. Chem. 201 (1953) 661-672.

2. Fry, B.A. Glutamine synthesis by Micrococcus pyogenes var. aureus. Biochem. J. 59 (1955) 579-589.

3. Lajtha, A., Mela, P. and Waelsch, H. Manganese-dependent glutamotransferase. J. Biol. Chem. 205 (1953) 553-564.

4. Meister, A. Glutamine synthesis, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 6, Academic Press, New York, 1962, pp. 443-468.

5. Woolfolk, C.A., Shapiro, B. and Stadtman, E.R. Regulation of glutamine synthetase. I. Purification and properties of glutamine synthetase from Escherichia coli. Arch. Biochem. Biophys. 116 (1966) 177-192. [PMID: 5336023]

[EC created 1961]

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