IUBMB Enzyme Nomenclature


Accepted name: NAD+ synthase

Reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+

Other name(s): NAD synthetase; NAD synthase; nicotinamide adenine dinucleotide synthetase; diphosphopyridine nucleotide synthetase

Systematic name: deamido-NAD+:ammonia ligase (AMP-forming)

Comments: L-Glutamine also acts, more slowly, as amido-donor [cf. EC, NAD+ synthase (glutamine-hydrolysing)].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9032-69-3


1. Spencer, R.L. and Preiss, J. Biosynthesis of diphosphopyridine nucleotide. The purification and the properties of diphosphopyridine nucleotide synthetase from Escherichia coli B. J. Biol. Chem. 242 (1967) 385-392. [PMID: 4290215]

[EC created 1972]

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