Reaction: glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate
For diagram click here.
Glossary: spermidine
Systematic name: glutathionylspermidine:glutathione ligase (ADP-forming)
Comments: involved in the synthesis of trypanothione in trypanosomatids
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 130246-69-4
References:
1. Smith, K., Nadeau, K., Bradley, M., Walsh, C.T., Fairlamb, A.H. Purification of glutathionyl spermidine and trypanothione synthase from Crithidia fasciculata. Protein Sci. 1 (1992) 874-883. [PMID: 1304372]