Reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + (ubiquitin)n-calmodulin
Other name(s): ubiquityl-calmodulin synthase; ubiquitin-calmodulin synthetase; ubiquityl-calmodulin synthetase; uCaM-synthetase
Systematic name: calmodulin:ubiquitin ligase (AMP-forming)
Comments: Specific for Ca2+-calmodulin from vertebrates. At least three ubiquitin molecules can be coupled to lysine residues in calmodulin.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number: 119632-60-9
References:
1. Jennissen, H.P. and Laub, M. Ubiquitin-calmodulin conjugating activity from cardiac muscle. Biol. Chem. Hoppe-Seyler 369 (1988) 1325-1330. [PMID: 2853950]
2. Ziegenhagen, R. and Jennissen, H.P. Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase. Biol. Chem. Hoppe-Seyler 369 (1988) 1317-1324. [PMID: 2853949]