IUBMB Enzyme Nomenclature


Accepted name: glutathione synthase

Reaction: ATP + γ-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

For diagram of reaction click here.

Other name(s): glutathione synthetase; GSH synthetase

Systematic name: γ-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-62-5


1. Law, M.Y. and Halliwell, B. Purification and properties of glutathione synthetase from (Spinacia oleracea) leaves. Plant Sci. 43 (1986) 185-191.

2. Macnicol, P.K. Homoglutathione and glutathione synthetases of legume seedlings - partial-purification and substrate-specificity. Plant Sci. 53 (1987) 229-235.

[EC created 1961]

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