Reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + D-lysine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-D-lysine
Other name(s): UDP-MurNAc-L-Ala-D-Glu:D-Lys ligase; D-lysine-adding enzyme
Systematic name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine α-ligase (ADP-forming)
Comments: The enzyme from Thermotoga maritima also performs the reaction of EC 220.127.116.11, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–L-lysine ligase. Involved in the synthesis of cell-wall peptidoglycan.
Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number:
1. Boniface, A., Bouhss, A., Mengin-Lecreulx, D. and Blanot, D. The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity. J. Biol. Chem. 281 (2006) 15680-15686. [PMID: 16595662]