IUBMB Enzyme Nomenclature


Accepted name: dethiobiotin synthase

Reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin

Other name(s): desthiobiotin synthase

Systematic name: 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)

Comments: CTP has half the activity of ATP.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37259-75-9


1. Krell, K. and Eisenberg, M.A. The purification and properties of dethiobiotin synthetase. J. Biol. Chem. 245 (1970) 6558-6566. [PMID: 4921568]

2. Yang, H.-C., Tani, Y. and Ogata, K. Synthesis of biotin vitamers from biotin diaminocarboxylic acid or 7,8-diaminopelargonic acid by a purified enzyme of Pseudomonas graveolens. Agric. Biol. Chem. 34 (1970) 1748-1750.

[EC created 1976]

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