IUBMB Enzyme Nomenclature


Accepted name: phosphoribosylamine—glycine ligase

Reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide

For reaction pathway click here.

Other name(s): phosphoribosylglycinamide synthetase; glycinamide ribonucleotide synthetase; phosphoribosylglycineamide synthetase; glycineamide ribonucleotide synthetase; 2-amino-N-ribosylacetamide 5'-phosphate kinosynthase; 5'-phosphoribosylglycinamide synthetase; GAR

Systematic name: 5-phospho-D-ribosylamine:glycine ligase (ADP-forming)

Comments: Formerly EC

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9032-01-3


1. Goldthwait, D.A., Peabody, R.A. and Greenberg, G.R. On the mechanism of synthesis of glycinamide ribotide and its formyl derivative. J. Biol. Chem. 221 (1956) 569-577.

2. Hartman, S.C. and Buchanan, J.M. Biosynthesis of the purines. XXII. 2-Amino-N-ribosylacetamide-5'-phosphate kinosynthase. J. Biol. Chem. 233 (1958) 456-461.

[EC created 1961 as EC, transferred 1972 to EC, modified 2000]

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