Reaction: ATP + UTP + NH3 = ADP + phosphate + CTP
Other name(s): UTP—ammonia ligase; cytidine triphosphate synthetase; uridine triphosphate aminase; cytidine 5'-triphosphate synthetase
Systematic name: UTP:ammonia ligase (ADP-forming)
Comments: Glutamine can replace NH3.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-56-7
References:
1. Lieberman, I. Enzymatic amination of uridine triphosphate to cytidine triphosphate. J. Biol. Chem. 222 (1956) 765-775.
2. Long, C.W., Levitzki, A., Houston, L.L and Koshland, D.E., Jr. Subunit structures and interactions of CTP synthetase. Fed. Proc. 28 (1969) 342 only.