Reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
For diagram click here.
Other name(s): GMP synthetase (glutamine-hydrolysing); guanylate synthetase (glutamine-hydrolyzing); guanosine monophosphate synthetase (glutamine-hydrolyzing); xanthosine 5'-phosphate amidotransferase; guanosine 5'-monophosphate synthetase
Systematic name: xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Links to other databases: BRENDA, EXPASY, KEGG, PDB, CAS registry number: 37318-71-1
References:
1. Abrams, R. and Bentley, M. Biosynthesis of nucleic acid purines. III. Guanosine 5'-phosphate formation from xanthosine 5'-phosphate and L-glutamine. Arch. Biochem. Biophys. 79 (1959) 91-110.
2. Lagerkvist, U. Biosynthesis of guanosine 5'-phosphate. II. Amination of xanthosine 5'-phosphate by purified enzyme from pigeon liver. J. Biol. Chem. 233 (1958) 143-149.