IUBMB Enzyme Nomenclature

EC 6.4.1.2

Accepted name: acetyl-CoA carboxylase

Reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

Other name(s): acetyl coenzyme A carboxylase

Systematic name: acetyl-CoA:carbon-dioxide ligase (ADP-forming)

Comments: A biotinyl-protein. Also catalyses transcarboxylation; the plant enzyme also carboxylates propanonyl-CoA and butanoyl-CoA.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-93-2

References:

1. Hatch, M.D. and Stumpf, P.K. Fat metabolism in higher plants. XVI. Acetyl coenzyme A carboxylase and acyl coenzyme A-malonyl coenzyme A transcarboxylase from wheat germ. J. Biol. Chem. 236 (1961) 2879-2885.

2. Matsuhashi, M., Matsuhashi, S. and Lynen, F. Zur Biosynthese der Fettsäuren. V. Die Acetyl-CoA Carboxylase aus Rattenleber und ihre Aktivierung durch Citronsäure. Biochem. Z. 340 (1964) 263-289.

3. Matsuhashi, M., Matsuhashi, S., Numa, S. and Lynen, F. [On the biosynthesis of fatty acids. IV. Acetyl-CoA carboxylase from yeast.] Biochem. Z. 340 (1964) 243-262.

4. Vagelos, P. Regulation of fatty acid biosynthesis. Curr. Top. Cell. Regul. 4 (1971) 119-166.

5. Wakil, S.J. A malonic acid derivative as an intermediate in fatty acid synthesis. J. Am. Chem. Soc. 80 (1958) 6465 only.

[EC 6.4.1.2 created 1961]


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