IUBMB Enzyme Nomenclature

EC 6.4.1.3

Accepted name: propionyl-CoA carboxylase

Reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

Other name(s): propionyl coenzyme A carboxylase

Systematic name: propanoyl-CoA:carbon-dioxide ligase (ADP-forming)

Comments: A biotinyl-protein. Also carboxylates butanoyl-CoA and catalyses transcarboxylation.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9023-94-3

References:

1. Kaziro, Y., Ochoa, S., Warner, R.C. and Chen, J.-Y. Metabolism of propionic acid in animal tissues. VIII. Crystalline propionyl carboxylase. J. Biol. Chem. 236 (1961) 1917-1923.

2. Lane, M.D., Halenz, D.R., Kosow, D.P. and Hegre, C.S. Further studies on mitochondrial propionyl carboxylase. J. Biol. Chem. 235 (1960) 3082-3086.

3. Meyer, H., Nevaldine, B. and Meyer, F. Acyl-coenzyme A carboxylase of the free-living nematode Turbatrix aceti. 1. Its isolation and molecular characteristics. Biochemistry 17 (1978) 1822-1827. [PMID: 656363]

4. Moss, J. and Lane, M.D. The biotin-dependent enzymes. Adv. Enzymol. Relat. Areas Mol. Biol. 35 (1971) 321-442. [PMID: 4150153]

5. Vagelos, P. Regulation of fatty acid biosynthesis. Curr. Top. Cell. Regul. 4 (1971) 119-166.

[EC 6.4.1.3 created 1961, modified 1983]


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