IUBMB Enzyme Nomenclature

EC 6.4.1.7

Accepted name: 2-oxoglutarate carboxylase

Reaction: ATP + 2-oxoglutarate + HCO3- = ADP + phosphate + oxalosuccinate

For diagram click here.

Glossary: oxalosuccinate = 1-oxopropane-1,2,3-tricarboxylate

Other name(s): oxalosuccinate synthetase; carboxylating factor for ICDH (incorrect); CFI; OGC

Comments: A biotin-containing enzyme that requires Mg2+ for activity. It was originally thought [1] that this enzyme was a promoting factor for the carboxylation of 2-oxoglutarate by EC 1.1.1.41, isocitrate dehydrogenase (NAD+), but this has since been disproved [2]. The product of the reaction is unstable and is quickly converted into isocitrate by the action of EC 1.1.1.41 [2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 60382-75-4

References:

1. Aoshima, M., Ishii, M. and Igarashi, Y. A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6. Mol. Microbiol. 51 (2004) 791-798. [PMID: 14731279]

2. Aoshima, M. and Igarashi, Y. A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6. Mol. Microbiol. 62 (2006) 748-759. [PMID: 17076668]

[EC 6.4.1.7 created 2006]


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