Reaction: NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + nicotinamide β-D-ribonucleotide + (deoxyribonucleotide)n+m
Other name(s): polydeoxyribonucleotide synthase (NAD); polynucleotide ligase (NAD); DNA repair enzyme; DNA joinase; DNA ligase (NAD); polynucleotide synthetase (nicotinamide adenine dinucleotide); deoxyribonucleic-joining enzyme; deoxyribonucleic ligase; deoxyribonucleic repair enzyme; deoxyribonucleic joinase; DNA ligase; DNA joinase; deoxyribonucleate ligase; polynucleotide ligase; deoxyribonucleic acid ligase; polynucleotide synthetase; deoxyribonucleic acid joinase; DNA-joining enzyme; deoxyribonucleic joinase; deoxyribonucleic repair enzyme; polynucleotide ligase (nicotinamide adenine dinucleotide); polydeoxyribonucleotide synthase (NAD+)
Systematic name: poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
Comments: Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37259-52-2
1. Zimmerman, S.B., Little, J.W., Oshinsky, C.K. and Gellert, M. Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide. Proc. Natl. Acad. Sci. USA 57 (1967) 1841-1848. [PMID: 4291949]