IUBMB Enzyme Nomenclature


Accepted name: RNA ligase (ATP)

Reaction: ATP + (ribonucleotide)n + (ribonucleotide)m = AMP + diphosphate + (ribonucleotide)n+m

Other name(s): polyribonucleotide synthase (ATP); RNA ligase; polyribonucleotide ligase; ribonucleic ligase

Systematic name: poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)

Comments: Converts linear RNA to a circular form by transfer of the 5'-phosphate to the 3'-hydroxy terminus.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37353-39-2


1. Silber, R., Malathi, V.G. and Hurwitz, J. Purification and properties of bacteriophage T4-induced RNA ligase. Proc. Natl. Acad. Sci. USA 69 (1972) 3009-3013. [PMID: 4342972]

[EC created 1976]

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