IUBMB Enzyme Nomenclature

EC 6.5.1.4

Accepted name: RNA 3'-terminal-phosphate cyclase (ATP)

Reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

Other name(s): RNA cyclase (ambiguous); RNA-3'-phosphate cyclase (ambiguous)

Systematic name: RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)

Comments: Adenosine 5'-(γ-thio)triphosphate can act instead of ATP. cf. EC 6.5.1.5, RNA-3'-phosphate cyclase (GTP).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 85638-41-1

References:

1. Filipowicz, W., Konarska, M., Gross, H.J. and Shatkin, A.J. RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res. 11 (1983) 1405-1418. [PMID: 6828385]

2. Reinberg, D., Arenas, J. and Hurwitz, J. The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives. J. Biol. Chem. 260 (1985) 6088-6097. [PMID: 2581947]

[EC 6.5.1.4 created 1986, modified 1989, modified 2013]


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