IUBMB Enzyme Nomenclature


Accepted name: RNA 3'-terminal-phosphate cyclase (ATP)

Reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

Other name(s): RNA cyclase (ambiguous); RNA-3'-phosphate cyclase (ambiguous)

Systematic name: RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)

Comments: Adenosine 5'-(γ-thio)triphosphate can act instead of ATP. cf. EC, RNA-3'-phosphate cyclase (GTP).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 85638-41-1


1. Filipowicz, W., Konarska, M., Gross, H.J. and Shatkin, A.J. RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract. Nucleic Acids Res. 11 (1983) 1405-1418. [PMID: 6828385]

2. Reinberg, D., Arenas, J. and Hurwitz, J. The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives. J. Biol. Chem. 260 (1985) 6088-6097. [PMID: 2581947]

[EC created 1986, modified 1989, modified 2013]

Return to EC 6.5.1 home page
Return to EC 6.5 home page
Return to EC 6 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page