Glycine Cleavage System

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© IUBMB 2003

The diagram shows how the lipoyl group of the H protein can visit the three enzymes of the multienzyme system of EC 1.4.4.2 glycine dehydrogenase (decarboxylating), EC 1.8.1.4 dihydrolipoyl dehydrogenase and EC 2.1.2.10 aminomethyltransferase, being transformed by each.


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C1 metabolism (folate coenzymes)
EC 1.4.4.2 glycine dehydrogenase (decarboxylating)
EC 1.8.1.4 dihydrolipoyl dehydrogenanse
EC 2.1.2.10 aminomethyltransferase