When cursor points to a box further details will be displayed in a tooltip window. If you click on the box you will change to appropriate reaction scheme or enzyme specification.
© IUBMB 2002
For more details of the stereochemistry of EC 18.104.22.168 citrate (Si)-synthase click here.
The overall result of the pathway shown is:
2 CH3-CO-S-CoA + 2 H2O + NAD+ = -OOC-CH2-CH2-COO- + 2 HS-CoA + NADH + 3 H+
Hence the possession of the two enzymes isocitrate lyase and malate synthase, in addition to the enzymes of the citric acid cycle, allows the bacteria and plants that possess them to convert fat into carbohydrate, a capability not possessed by most animals.
EC 22.214.171.124 malate dehydrogenase
EC 126.96.36.199 citrate (Si)-synthase
EC 188.8.131.52 malate synthase
EC 184.108.40.206 isocitrate lyase
EC 220.127.116.11 aconitate hydratase