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© IUBMB 2002
For more details of the stereochemistry of EC 220.127.116.11 citrate (Si)-synthase click here.
The overall result of the pathway shown is:
2 CH3-CO-S-CoA + 2 H2O + NAD+ = -OOC-CH2-CH2-COO- + 2 HS-CoA + NADH + 3 H+
Hence the possession of the two enzymes isocitrate lyase and malate synthase, in addition to the enzymes of the citric acid cycle, allows the bacteria and plants that possess them to convert fat into carbohydrate, a capability not possessed by most animals.
EC 18.104.22.168 malate dehydrogenase
EC 22.214.171.124 citrate (Si)-synthase
EC 126.96.36.199 malate synthase
EC 188.8.131.52 isocitrate lyase
EC 184.108.40.206 aconitate hydratase