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© IUBMB 2002
For more details of the stereochemistry of EC 126.96.36.199 citrate (Si)-synthase click here.
The overall result of the pathway shown is:
2 CH3-CO-S-CoA + 2 H2O + NAD+ = -OOC-CH2-CH2-COO- + 2 HS-CoA + NADH + 3 H+
Hence the possession of the two enzymes isocitrate lyase and malate synthase, in addition to the enzymes of the citric acid cycle, allows the bacteria and plants that possess them to convert fat into carbohydrate, a capability not possessed by most animals.
EC 188.8.131.52 malate dehydrogenase
EC 184.108.40.206 citrate (Si)-synthase
EC 220.127.116.11 malate synthase
EC 18.104.22.168 isocitrate lyase
EC 22.214.171.124 aconitate hydratase