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© IUBMB 2002
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 126.96.36.199 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 188.8.131.52 in other Gram-positive organisms.
2. The enzyme EC 184.108.40.206 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
peptidoglycan biosynthesis (part 2)
EC 220.127.116.11 UDP-N-acetylmuramate dehydrogenase
EC 18.104.22.168 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 22.214.171.124 D-alanineD-alanine ligase
EC 126.96.36.199 UDP-N-acetylmuramoyl-L-alanyl-D-glutamateL-lysine ligase
EC 188.8.131.52 UDP-N-acetylmuramateL-alanine ligase
EC 184.108.40.206 UDP-N-acetylmuramoylalanineD-glutamate ligase
EC 220.127.116.11 UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 18.104.22.168 UDP-N-acetylmuramoylalanyl-D-glutamate2,6-diaminopimelate ligase