Peptidoglycan Biosynthesis (Part 1)

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© IUBMB 2002


1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC in Gram-negative and some Gram-positive organisms. Lysine is added by EC in other Gram-positive organisms.

2. The enzyme EC attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.

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UDP-N-acetylglucosamine biosynthesis
peptidoglycan biosynthesis (part 2)
EC UDP-N-acetylmuramate dehydrogenase
EC UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC D-alanine—D-alanine ligase
EC UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
EC UDP-N-acetylmuramate—L-alanine ligase
EC UDP-N-acetylmuramoylalanine—D-glutamate ligase
EC UDP-N-acetylmuramoyl-tripeptide—D-alanyl-D-alanine ligase
EC UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diaminopimelate ligase