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© IUBMB 2002
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 22.214.171.124 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 126.96.36.199 in other Gram-positive organisms.
2. The enzyme EC 188.8.131.52 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
peptidoglycan biosynthesis (part 2)
EC 184.108.40.206 UDP-N-acetylmuramate dehydrogenase
EC 220.127.116.11 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 18.104.22.168 D-alanineD-alanine ligase
EC 22.214.171.124 UDP-N-acetylmuramoyl-L-alanyl-D-glutamateL-lysine ligase
EC 126.96.36.199 UDP-N-acetylmuramateL-alanine ligase
EC 188.8.131.52 UDP-N-acetylmuramoylalanineD-glutamate ligase
EC 184.108.40.206 UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 220.127.116.11 UDP-N-acetylmuramoylalanyl-D-glutamate2,6-diaminopimelate ligase