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© IUBMB 2002
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 188.8.131.52 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 184.108.40.206 in other Gram-positive organisms.
2. The enzyme EC 220.127.116.11 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
peptidoglycan biosynthesis (part 2)
EC 18.104.22.168 UDP-N-acetylmuramate dehydrogenase
EC 22.214.171.124 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 126.96.36.199 D-alanineD-alanine ligase
EC 188.8.131.52 UDP-N-acetylmuramoyl-L-alanyl-D-glutamateL-lysine ligase
EC 184.108.40.206 UDP-N-acetylmuramateL-alanine ligase
EC 220.127.116.11 UDP-N-acetylmuramoylalanineD-glutamate ligase
EC 18.104.22.168 UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 22.214.171.124 UDP-N-acetylmuramoylalanyl-D-glutamate2,6-diaminopimelate ligase