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© IUBMB 2002
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 220.127.116.11 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 18.104.22.168 in other Gram-positive organisms.
2. The enzyme EC 22.214.171.124 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
peptidoglycan biosynthesis (part 2)
EC 126.96.36.199 UDP-N-acetylmuramate dehydrogenase
EC 188.8.131.52 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 184.108.40.206 D-alanineD-alanine ligase
EC 220.127.116.11 UDP-N-acetylmuramoyl-L-alanyl-D-glutamateL-lysine ligase
EC 18.104.22.168 UDP-N-acetylmuramateL-alanine ligase
EC 22.214.171.124 UDP-N-acetylmuramoylalanineD-glutamate ligase
EC 126.96.36.199 UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 188.8.131.52 UDP-N-acetylmuramoylalanyl-D-glutamate2,6-diaminopimelate ligase