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© IUBMB 2002
1. meso-2,6-Diaminopimelate (2,6-diaminoheptanoate, A2pm) is added by EC 18.104.22.168 in Gram-negative and some Gram-positive organisms. Lysine is added by EC 22.214.171.124 in other Gram-positive organisms.
2. The enzyme EC 126.96.36.199 attaches D-Ala-D-Ala to the C-terminal residue whether it is lysine or diaminopimelate. Subsequent enzymes in the pathway act regardless of which of these residues is present in their substrates.
peptidoglycan biosynthesis (part 2)
EC 188.8.131.52 UDP-N-acetylmuramate dehydrogenase
EC 184.108.40.206 UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC 220.127.116.11 D-alanineD-alanine ligase
EC 18.104.22.168 UDP-N-acetylmuramoyl-L-alanyl-D-glutamateL-lysine ligase
EC 22.214.171.124 UDP-N-acetylmuramateL-alanine ligase
EC 126.96.36.199 UDP-N-acetylmuramoylalanineD-glutamate ligase
EC 188.8.131.52 UDP-N-acetylmuramoyl-tripeptideD-alanyl-D-alanine ligase
EC 184.108.40.206 UDP-N-acetylmuramoylalanyl-D-glutamate2,6-diaminopimelate ligase