Peptidoglycan Biosynthesis (Part 2)

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© IUBMB 2002


1. The third residue in the pentapeptide is meso-2,6-diaminopimelate (2,6-diaminoheptanedioate, A2pm) in Gram-negative and some Gram-positive organisms. It is lysine in other Gram-positive organisms. Both peptide bonds of the diaminopimelic residue are to its L-centre.

2. For the reaction of EC to be predominantly in the forward direction, a high cytoplasmic concentration (about 0.1 mM) of the UDP-Mur2Ac-pentapeptide is required.

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UDP-N-acetylglucosamine biosynthesis
peptidoglycan biosynthesis (part 1)
peptidoglycan biosynthesis (part 3)
EC undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase
EC phospho-N-acetylmuramoyl-pentapeptide-transferase