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© IUBMB 2002
1. The third residue in the pentapeptide is meso-2,6-diaminopimelate (2,6-diaminoheptanedioate, A2pm) in Gram-negative and some Gram-positive organisms. It is lysine in other Gram-positive organisms. Both peptide bonds of the diaminopimelic residue are to its L-centre.
2. For the reaction of EC 220.127.116.11 to be predominantly in the forward direction, a high cytoplasmic concentration (about 0.1 mM) of the UDP-Mur2Ac-pentapeptide is required.
peptidoglycan biosynthesis (part 1)
peptidoglycan biosynthesis (part 3)
EC 18.104.22.168 undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase
EC 22.214.171.124 phospho-N-acetylmuramoyl-pentapeptide-transferase